Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity / Kim, Kyung Mok
Hematopoietic stem cells (HSC) - the unique tissue-specific stem cells in the bone marrow - are responsible for maintaining the stem cell pool and replenishing all types of blood cells in a lifetime. The balance between differentiation and self-renewal potential of HSC is essential to maintain immune balance. HSCs gradually lose their regenerative potential, and produce fewer lymphoid cells during aging. Although old HSCs show a functional decline, they still maintain minimal functionality. I uncovered a protective role of TAZ in HSCs during aging. TAZ plays a transcriptional coactivator of PU.1 which is a key regulator of the HSC function. Upregulated TAZ buffers an age-associated decline of PU.1 activity to maintain a minimal regenerative potential. In addition, I found an aging surface marker “Clca3a1” that is a proxy for the TAZ activity. Old LT-HSCs are heterogenous consisting of “true” aged HSCs and “young-like” HSCs. We anticipate that these findings provide a better understanding of HSC aging and contribute to uncovering a future therapeutic target for HSC rejuvenation.
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| Medienart: | E-Book |
| Sprache(n): | Englisch |
| Publikation: | Jena, 2023 |
| Hochschulschrift: | Dissertation, Friedrich-Schiller-Universität Jena, 2023 |
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| Art des Inhalts: | Abschlussarbeit |
| Umfang: | 123 Seiten |
| URN: | urn:nbn:de:gbv:27-dbt-20231005-102433-001 |
| Access Status: | Open Access |
| Rechteinformation: | Creative Commons 4.0 International Lizenzen |
| DDC-Sachgruppe(n) der DNB: | 610 Medizin und Gesundheit |
| Quelle: | Digitale Bibliothek Thüringen (DBT) |
