Adhesion G protein-coupled receptors : molecular, physiological and pharmacological principles in health and disease / Tobias Langenhan, Torsten Schöneberg, editors

Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function

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Persons: Langenhan, Tobias [Editor]; Schöneberg, Torsten [Editor]
Format: eBook
Language(s):English
Publication:Cham : Springer, [2016]
Part of:Handbook of experimental pharmacology 234
Subjects:Medicine
Human genetics
Human physiology
Pharmacology
Medical biochemistry
Cell biology
GTP-Binding Proteins
Receptors, G-Protein-Coupled
Signal Transduction
Related resources:Printed edition: ISBN 9783319415215
Notes:Includes bibliographical references and index
Physical description:1 Online-Ressource (xiv, 403 Seiten) : Illustrationen
Reproduction:Online-Ausg., Springer eBook Collection. Biomedical and Life Sciences
ISBN:978-3-319-41523-9
DOI:10.1007/978-3-319-41523-9