Secondary metabolites from predatory bacteria : isolation, structure elucidation and bioactivity / von Sebastian Schieferdecker

Natural products are privileged structures for the identification of novel bioactive lead compounds in drug discovery. They proved to be of particular value in the field of antimicrobial and antiproliferative chemotherapy. Especially the advent of drug-resistant human pathogenic bacteria necessitates the discovery of novel compounds with innovative mode of actions. The aim of this thesis was to isolate bioactive secondary metabolites as potential lead compounds for the development of innovative antimicrobial and antiproliferative therapeutics. This thesis deals with the bioactivity-guided isolation of antimicrobial and antiproliferative compounds from culture extracts of predatory bacteria. The investigated organisms included the two myxobacteria Pyxidicoccus fallax HKI 727 and Myxococcus fulvus HKI 722, as well as the filamentous bacterium Herpetosiphon aurantiacus DSM 785.

Saved in:
Person: Schieferdecker, Sebastian [Author]
Corporate Author: Friedrich-Schiller-Universit├Ąt Jena [Degree granting institution]
Format: eBook
Language(s):English
Publication:Jena, 2015
Printing place:Jena
Dissertation Note:Jena, Univ., Diss., 2015
Type of content:Hochschulschrift
Related resources:Erscheint auch als Druck-Ausgabe: Secondary metabolites from predatory bacteria
Physical description:1 Online-Ressource (179 Seiten) : Ill., graph. Darst.
URN:urn:nbn:de:gbv:27-20150831-120612-9
Basic Classification: 35.50 Organische Chemie: Allgemeines
42.30 Mikrobiologie
35.79 Biochemie: Sonstiges