Novel evasion strategies of Staphylococcus aureus against the human innate immune response / von Tina Katrin Koch

There is an ongoing competition between the human host and pathogenic microbes. The immune system, especially the immediately acting innate response, recognizes pathogens, prevents their spreading, and eliminates them. By contrast, certain microbes have developed sophisticated strategies to evade and suppress the host immune response. This thesis focuses on the functions of the plasma proteins apolipoprotein E (apoE)and plasmin in the interactions between the human host and the pathogen Staphylococcus aureus. Here, it is shown that antimicrobial peptides (AMPs) were generated from apoE upon cleavage by neutrophil elastase. The bactericidal activity was located to the heparin-binding site of the LDL-receptor-binding domain of apoE (SHL14). Full-length apoE had no antibacterial, but opsonic activity. Additionally, a new function of plasmin is reported. ...

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Person: Koch, Tina Katrin [Author]
Corporate Author: Friedrich-Schiller-Universität Jena [Degree granting institution]
Format: Book
Language(s):English
Publication:Jena, 2012
Printing place:Jena
Dissertation:Jena, Univ., Diss., 2012
Type of content:Hochschulschrift
Related resources:Erscheint auch als Online-Ausgabe: Novel evasion strategies of Staphylococcus aureus against the human innate immune response
Physical description:VIII, 80, [5] Bl. : Ill., graph. Darst. ; 30 cm
Basic Classification: 44.45 Immunologie
35.73 Biochemische Reaktionen