Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study / Ricarda von Krüchten, Roberto Lorbeer, Christopher Schuppert, Corinna Storz, Blerim Mujaj, Holger Schulz, Hans-Ulrich Kauczor, Annette Peters, Fabian Bamberg, Stefan Karrasch & Christopher L. Schlett

To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3 ± 9.2 years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (ß = − 0.14, p = 0.01), early diastolic filling rate (ß = − 0.11, p = 0.04), and LV/RV stroke volume (ß = − 0.14, p = 0.01; ß = − 0.11, p = 0.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT.

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Persons: Krüchten, Ricarda von [Author]; Lorbeer, Roberto [Author]; Schuppert, Christopher [Author]; Storz, Corinna [Author]; Mujaj, Blerim [Author]; Schulz, Holger [Author]; Kauczor, Hans-Ulrich [Author]; Peters, Annette [Author]; Bamberg, Fabian [Author]; Karrasch, Stefan [Author]; Schlett, Christopher L. [Author]
Format: eArticle
Language(s):English
Publication:09 August 2021
Part of:Scientific reports 11(2021), Artikel-ID 16173, Seite 1-9
Notes:Gesehen am 02.10.2021
Physical description:9
ISSN:2045-2322
DOI:10.1038/s41598-021-95655-7