Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma / Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M.L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L.B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino & Thomas G.P. Grünewald

Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by fusion oncoproteins involving EWSR1 and variable members of the ETS-family of transcription factors (in 85% FLI1). EWSR1-FLI1 can induce target genes by using GGAA-microsatellites as enhancers.

Saved in:
Persons: Marchetto, Aruna [Author]; Ohmura, Shunya [Author]; Orth, Martin F. [Author]; Knott, Maximilian M. L. [Author]; Colombo, Maria V. [Author]; Arrigoni, Chiara [Author]; Bardinet, Victor [Author]; Saucier, David [Author]; Wehweck, Fabienne S. [Author]; Li, Jing [Author]; Stein, Stefanie [Author]; Gerke, Julia S. [Author]; Baldauf, Michaela C. [Author]; Musa, Julian [Author]; Dallmayer, Marlene [Author]; Romero-Pérez, Laura [Author]; Hölting, Tilman L. B. [Author]; Amatruda, James F. [Author]; Cossarizza, Andrea [Author]; Henssen, Anton G. [Author]; Kirchner, Thomas [Author]; Moretti, Matteo [Author]; Cidre-Aranaz, Florencia [Author]; Sannino, Giuseppina [Author]; Grünewald, Thomas Georg Philipp [Author]
Format: eArticle
Language(s):English
Publication:15 May 2020
Part of:Nature Communications 11(2020), Artikel-ID 2423, Seite 1-16
Notes:Gesehen am 06.04.2021
Physical description:16
ISSN:2041-1723
DOI:10.1038/s41467-020-16244-2