Structural investigations on heme-interacting proteins = Strukturelle Untersuchung an Häm-bindenden Proteinen / by M.Sc. Biotechnology Amit Kumar

Heme is a widely known cofactor molecule in many enzymes like hemoglobin, cytochromes, and myoglobins. It is attached to these proteins covalently and classifies them as hemoproteins. In the last decade, a growing number of reports on the regulatory role of heme in various molecular and cellular processes uncovered the signaling role of heme. Here, heme binds transiently or with a low affinity to a variety of proteins and regulates their function. Inspite of the number of reports on its regulatory role, they are poorly defined at the structural level. Heme binds to these proteins through special amino acids called heme regulatory motifs (HRMs) such as cysteine-proline (CP), histidine and tyrosine. Studies conducted on CBS and the IL-36 cytokine family members during this project validated the heme-peptide knowledge at the protein level.

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Persons: Kumar, Amit [Author]; Heinemann, Stefan H. [Degree supervisor]; Pospiech, Helmut [Degree supervisor]; Fattorussa, Roberto [Degree supervisor]
Corporate Author: Friedrich-Schiller-Universität Jena [Degree granting institution]
Format: Book
Language(s):English, German
Language note:Zusammenfassungen in deutscher und englischer Sprache
Publication:Jena, [2019?]
Printing place:Jena
Dissertation Note:Dissertation, Friedrich-Schiller-Universität Jena, 2019
Type of content:Hochschulschrift
Related resources:Erscheint auch als Online-Ausgabe: Structural investigations on heme-interacting proteins
Notes:Kumulative Dissertation, enthält Zeitschriftenaufsätze
Tag der Verteidigung: 17.12.2019
Physical description:circa 166 Seiten : Illustrationen, Diagramme ; 30 cm
Basic Classification: 35.71 Biochemische Methoden
35.74 Enzyme, Hormone, Vitamine
44.86 Hämatologie