Vacuolar/lysosomal proteolysis : proteases, substrates, mechanisms / Michael Knop, Hans H Schiffer, Steffen Rupp and Dieter H Wolf

Proteolysis is an essential post-transcriptional process. The lysosome/vacuole is the central organelle for non-specific proteolysis in eukaryotes. Most proteases that work in the lysosome enter it via the secretory pathway. The bulk of proteins to be degraded enter this proteolytic compartment via endocytosis and autophagocytosis. Our understanding of the mechanisms involved in these processes has increased considerably, and the information obtained in these studies has enabled new, specific proteolytic pathways to be investigated in other cellular compartments, particularly in the cytoplasm.

Saved in:
Persons: Knop, Michael [Author]; Rupp, Steffen [Author]; Wolf, Dieter H. [Author]
Format: eArticle
Language(s):English
Publication:2004
Part of:Current opinion in cell biology 5(1993), 6, Seite 990-996
Subjects:Saccharomyces cerevisiae
Animals
Fungal Proteins
Biological Transport
Catalysis
Endocytosis
Endopeptidases
Enzyme Activation
Eukaryotic Cells
Lysosomes
Phagocytosis
Protein Processing, Post-Translational
Substrate Specificity
Vacuoles
Notes:Available online 24 February 2004
Gesehen am 31.08.2017
Physical description:7
ISSN:1879-0410
DOI:10.1016/0955-0674(93)90082-2