Effects of miR-141-containing extracellular vesicles in the regulation of endothelial tube formation by trophoblastic cells / Ruby Nicole Gutiérrez-Samudio

Preeclampsia constitutes a hypertensive disorder exclusive to pregnancy. It is a systemic disease with multi-organ involvement that complicates between 2 - 8% of all pregnancies, remaining one of the primary causes of maternal and perinatal morbidity and mortality in the world. Preeclampsia has been associated with improper extravillous trophoblast invasion into uterine spiral arteries and deficiency of their remodeling. Previous studies have revealed that trophoblast cells secrete microRNAs (miRNAs) into the maternal circulation by packing them within extracellular vesicles (EVs). This process takes place in normal and in preeclamptic pregnancies, but at different quantities and qualities, indicating its potential role in physiology and pathology of the placenta. EVs are present in maternal plasma from early pregnancy onwards, which represents potential diagnostic tools as biomarkers for gestational pathologies. ...

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Person: Gutiérrez-Samudio, Ruby Nicole [Author]
Corporate Author: Friedrich-Schiller-Universität Jena [Degree granting institution]
Format: Book
Language(s):English
Language note:Zusammenfassungen in deutscher und englischer Sprache
Publication:Jena, 2018
Printing place:Jena
Dissertation Note:Dissertation, Friedrich-Schiller-Universität Jena, 2018
Subjects:Schwangerschaft > Präeklampsie > Trophoblast > miRNS
Type of content:Hochschulschrift
Related resources:Erscheint auch als Online-Ausgabe: Effects of miR-141-containing extracellular vesicles in the regulation of endothelial tube formation by trophoblastic cells
Physical description:VI, 57 Seiten : Illustrationen, Diagramme ; 30 cm
Basic Classification: 44.92 Gynäkologie